Somites are transient structures which represent the most overt segmental feature of the vertebrate embryo. The strict temporal regulation of somitogenesis is of critical developmental importance since many segmental structures adopt a periodicity based on that of the somites. Until recently, the mechanisms underlying the periodicity of somitogenesis were largely unknown. Based on the oscillations of c-hairy1 and lunatic fringe RNA, we now have evidence for an intrinsic segmentation clock in presomitic cells. Translation of this temporal periodicity into a spatial (...) periodicity, through somite formation, requires Notch signaling. While the Hox genes are certainly involved, it remains unknown how the metameric vertebrate axis becomes regionalized along the antero–posterior (AP) dimension into the occipital, cervical, thoracic, lumbar, and sacral domains. We discuss the implications of cell division as a clock mechanism underlying the regionalization of somites and their derivatives along the AP axis. Possible links between the segmentation clock and axial regionalization are also discussed. BioEssays 22:72–83, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

© JNCCN-Journal of the National Comprehensive Cancer Network.Background: Next-generation tumor sequencing panels, which include multiple established and novel targets across cancers, are emerging in oncology practice, but lack formal positive coverage by US payers. Lack of coverage may impact access and adoption. This study identified challenges of NGTS coverage by private payers.Methods: We conducted semi-structured interviews with 14 NGTS experts on potential NGTS benefits, and with 10 major payers, representing more than 125,000,000 enrollees, on NGTS coverage considerations. We used the (...) framework approach of qualitative research for study design and thematic analyses and simple frequencies to further describe findings.Results: All interviewed payers see potential NGTS benefits, but all noted challenges to formal coverage: 80% state that inherent features of NGTS do not fit the medical necessity definition required for coverage, 70% view NGTS as a bundle of targets versus comprehensive tumor characterization and may evaluate each target individually, and 70% express skepticism regarding new evidence methods proposed for NGTS. Fifty percent of payers expressed sufficient concerns about NGTS adoption and implementation that will preclude their ability to issue positive coverage policies.Conclusions: Payers perceive that NGTS holds significant promise but, in its current form, poses disruptive challenges to coverage policy frameworks. Proactive multidisciplinary efforts to define the direction for NGTS development, evidence generation, and incorporation into coverage policy are necessary to realize its promise and provide patient access. This study contributes to current literature, as possibly the first study to directly interview US payers on NGTS coverage and reimbursement. (shrink)

Participants were asked to draw inferences about correlation from single x,y observations. In Experiment 1 statistically sophisticated participants were given the univariate characteristics of distributions of x and y and asked to infer whether a single x, y observation came from a correlated or an uncorrelated population. In Experiment 2, students with a variety of statistical backgrounds assigned posterior probabilities to five possible populations based on single x, y observations, again given knowledge of the univariate statistics. In Experiment 3, statistically (...) naïve participants were given a problem analogous to that given in Experiment 1, framed verbally. Experiment 4 replicated Experiment 3 but added an “impossible to determine” response option. Models that rely on computing sample correlations make no predictions about these investigations. From a Bayesian perspective, participants’ inferences in all four experiments tended to make probabilistically valid inferences as long as the single datum was directional. The results are discussed in light of the Brunswikian notion of vicarious functioning. (shrink)

The paper constitutes a detailed critical commentary on Stephen Darwall’s Impartial Reason (Ithaca: Cornell University Press, 1983). Its central thesis is that Darwall’s attempt to integrate a naturalist theory of substantive reasons for acting with a neo-rationalist derivation of moral requirements from the very concept of practical rationality is faced with insurmountable theoretic problems. The author argues that anyone who would accept a plausible internalist account of reasons, that justificatory reasons for an agent to act are facts which must be (...) capable of motivating that agent under certain conditions, cannot establish on an a priori or rationalist basis claims for the intersubjective validity of reasons or substantive normative requirements of any kind, but rather must acknowledge that such claims are both irreducibly empirical and epistemically risky. (shrink)

We examine when and how police officers may avoid costly errors under stress by leveraging theoretical and empirical work on the biopsychosocial (BPS) model of challenge and threat. According to the BPS model, in motivated performance contexts (e.g., test taking, athletics), the evaluation of situational and task demands in relation to one’s perceived resources available to cope with those demands engenders distinct patterns of peripheral physiological responding. Individuals experience more challenge-like states in which blood circulates more efficiently in the periphery (...) when they evaluate their coping resources as meeting or exceeding the task demands. Conversely, individuals experience more threat-like states in which blood circulates less efficiently in the periphery when they view the situation or task demands as exceeding their coping resources. Patterns of response consistent with challenge and threat states have been shown to predict important performance and decision-making outcomes in stressful contexts, and repeated experiences of threat-like patterns of physiological activity are thought to have detrimental effects on long-term cardiovascular health. To date, however, research has not used the biopsychosocial model to understand police decision-making under stress. Here, we review relevant empirical work from the perspective of the BPS model concerning how minority status and power can shape challenge and threat responding and contribute to decision making under stress. We then detail a research agenda aimed at improving the translational value of research being conducted within the BPS model for understanding complex performance and decision making in the real world, including among law enforcement personnel. (shrink)

The paper constitutes a detailed critical commentary on Stephen Darwall’s Impartial Reason. Its central thesis is that Darwall’s attempt to integrate a naturalist theory of substantive reasons for acting with a neo-rationalist derivation of moral requirements from the very concept of practical rationality is faced with insurmountable theoretic problems. The author argues that anyone who would accept a plausible internalist account of reasons, that justificatory reasons for an agent to act are facts which must be capable of motivating that agent (...) under certain conditions, cannot establish on an a priori or rationalist basis claims for the intersubjective validity of reasons or substantive normative requirements of any kind, but rather must acknowledge that such claims are both irreducibly empirical and epistemically risky. (shrink)

This paper treats two problem cases in decision theory, the Newcomb problem and Reed Richter''s Button III. Although I argue that, contrary to Richter, the latter case does not constitute a genuine counterexample to a standard general proposition of (causal) decision theory, I agree with and undertake to amplify his solution to the decision problem in Button III. I then apply the conclusions and distinctions in the foregoing treatment of Button III to the Newcomb problem and argue that a familiar (...) version of the dominance argument for taking both boxes runs afoul of plausible general constraints on rational agency. The underlying theme of the paper is that basic considerations of epistemic coherence play an important role in dealing with problem cases in decision theory. (shrink)

Can you think of a meme that made you laugh or a political post that made you angry? These examples illustrate how social media use (SMU) impacts how people feel. Similarly, how people feel when they initiate SMU may impact the emotional effects of SMU. Someone feeling happy may feel more positively during SMU, whereas someone feeling sad may feel more negatively. Using an experimental design, we examined whether following SMU, those in a happy mood would experience increases in positive (...) affect (PA) and those in a sad mood would experience increases in negative affect (NA). A large sample of college students (N = 703) were randomly assigned to a happy, sad, or neutral mood induction before SMU. PA and NA were assessed at baseline, post-mood induction, and after SMU. Contrary to hypotheses, after SMU, people in happy moods experienced decreases in PA, and those in sad moods experienced decreases in NA, reflecting SMU having a dampening effect on emotions. PA and NA were significantly lower after SMU compared to baseline and did not vary by condition. How young adults feel when they log onto SMU matters in understanding how SMU impacts PA and NA, but on average, emotional experiences are dampened. (shrink)

The cytoskeleton has a central role in eukaryotic biology, enabling cells to organize internally, polarize, and translocate. Studying cytoskeletal machinery across the tree of life can identify common elements, illuminate fundamental mechanisms, and provide insight into processes specific to less‐characterized organisms. Red algae represent an ancient lineage that is diverse, ecologically significant, and biomedically relevant. Recent genomic analysis shows that red algae have a surprising paucity of cytoskeletal elements, particularly molecular motors. Here, we review the genomic and cell biological evidence (...) and propose testable models of how red algal cells might perform processes including cell motility, cytokinesis, intracellular transport, and secretion, given their reduced cytoskeletons. In addition to enhancing understanding of red algae and lineages that evolved from red algal endosymbioses (e.g., apicomplexan parasites), these ideas may also provide insight into cytoskeletal processes in animal cells. (shrink)

A collection of essays from some of the world's leading intellectual historians, representing an international spectrum of research into the history of philosophy, intellect, science and music. This collection of essays addresses, in specific historical ways and from particular disciplinary standpoints, the problem of knowledge and what used to be called the classification of the sciences. What is, or what passes for, knowledge? What are its divisions, and how should they be related? Who possesses this knowledge, and to what uses (...) has it been put? How is it transmitted, and how can its history be understood and written? Ranging across the epistemological barrier formed by the revolution of modern science, these contributions inquire into the changing disciplinary patterns of the tumultuous times between the renaissance and the enlightenment, that saw the fragmentation of old ideals and the creation of European modernity. Contributors: Donald R. Kelley, Ann Blair, Paul Nelles, Constance Blackwell, Ulrich Schneider, Martin Mulsow, J.B. Schneewind, Donald Verene, Peter Miller, Ann Moyers, Michael Seidler, Anthony Pagden, Paula Findlen, Anthony Grafton, Heikki Mikkeli, Nicholas Jardine, Londa Schiebinger. (shrink)

Arthur O. Lovejoy conceived of the history of ideas as an interdisciplinary study, encompassing a variety of fields, including literary history, comparative literature, the history of folklore and ethnography, the history of language and the history of religious beliefs. This volume gathers together some of the most significant articles concerning the theory and practice of intellectual history, by Lovejoy himself and other scholars. Contributors: DONALD R. KELLEY, ARTHUR O. LOVEJOY, FREDERICK J. TEGGART, LEO SPITZER, THEODORE SPENCER, ABRAHAM EDEL, PAUL (...) O. KRISTELLER, PHILIP P. WIENER, JOSEPH A. MAZZEO, LEONARD KRIEGER, DANIEL J. WILSON, EDWARD P. MAHONEY, FRANCIS OAKLEY,JOHANN HUIZINGA, JOSEPH KATZ, CALVIN G. RAND, NILS B. KVASTAD, LESTER G. CROCKER and PATRICK H. HUTTON. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:ROBERT ORFORD'S ATTACK ON GILES OF ROME I N TWO PREVIOUS ARTICLES, I tried to demonstrate how Robert Orford drew upon the thought of Giles of Rome in order to formulate his own explanation of hylomorphism and the so-called real distinction between essence and existence.1 Orford, it will be remembered, was one of the earliest disciples of his colleague St. Thomas Aquinas, and-more important- is the first 'llhomist we (...) know of who turned to Giles in order to gain an understanding of these basic philosophic problems, and who wove Giles's ideas into his own elaboration of what he took to be St. Thomas's position regarding them. In view of this recognition of Giles as an appropriate guide to a Thomist grasp of these issues, it is surprising to find among Orford's works the Reprobationes dfotorUJn a fratre Egidio in primum Sententiarum.2 The Reprobationes is a strange document. In it, as I shall show later, Orford seeks every opportunity to find fault with Giles. Indeed, his criticisms, hardly ever of any substance, are at times so "picky" they cause the reader to wonder as to his real purpose in writing them down in the first place. In this article, I shall review the historical context of the Reprobationes and try to show what it was about Giles of Rome that so irritated the Dominican Orford. The early catalogues contain no more than two entries for 1 See F. Kelley, "The Egidean influence in Robert Orford's doctrine on Form", Thomist, 47, 1, January, 1983, pp. 77-99, and "Two early English Thomists: Thomas Sutton and Robert Orford vs. Henry of Ghent", Thomist, 45, 3, July, 1981, pp. 345-387. 2 This work is extant in one manuscript, viz. MS. Merton 276, fol. 20ra50ra. It has been edited by A. Vella: Robert d'Orford Reprobationes dictorum a fratre Egidio in primum Sententiarum, Paris, 1968. 70 ROBERT ORFORD'S ATTACK ON GILES OF ROME 71 Orford.3 However, from references he made in his extant writings, viz., Sciendum, Contra dicta Henrici and Reprobationes, we know the titles at least of some of his other writings. As one might have expected, Orford wrote commentaries on the books of the Sentences. In addition to the references to these commentaries he mentions also a De unitate formae, Super 2 de sommo et vigilia, Super 6 de M etaphysica and De generatione. We know of Orford's part in certain disputed questions and of his sermon in rn93. Finally, we have offered our reasons elsewhere for attributing to him the opuscule entitled De natura materiae et dimensionibus interminatis.4 From the mere fact that Orford saw the necessity of writing against Giles of Rome in defense of St. Thomas Aquinas, one might have thought that in Giles one had found an antagonist of the Angelic Doctor. For a long time Giles was taken to have been not an adversary but rather a stout defender of his teacher, St. Thomas.5 The picture of Giles of Rome as the loyal Thomist, the legend as it has more recently been labelled, derived in no small measure from the erroneous ascription to him of the work which is in fact Richard Knapwell's, viz. Correctivum corruptorii 'Quare '.6 Once this mistaken ascription had been corrected and further study was done, mainly by E. Hocedez, Giles no longer appeared as having been the staunch and loyal Thomist of the legend. On the contrary, Hocedez says of him: Gilles decidement n'est pas le thomiste, clans le sens profond du mot, qui s'est donne Thomas pour Maitre et guide de sa pensee: a For a full account of what the catalogues have under Orford's name, see A. Vella, "Robert of Orford and his place in the scholastic controversies at Oxford in the late xiiith century" (Oxford Univ. B.Litt. thesis 1946), MS. B.Litt., c. 30, vol. 1, Bodleian Library, pp. 12-27. 4 See F. Kelley," The Egidean influence", pp. 90-96. 5 See F. Lajard, "Gilles de Rome", Histoire litteraire de la France, 30 (1888), pp. 421-566. 6 "Nous croyons que ce qui a le plus contribue a faire... (shrink)

The great problem in writing a theory of everything is that it may turn out to be a theory of nothing. Here is how it works. If you develop a theory that only explains some small, simple Thing, then the theory is very strong. It is precise, understandable, and it always works. As you expand the theory to encompass another Thing, it becomes weaker. It may still be precise and understandable, but it is now more complicated, and because it involves (...) two things rather than one, it starts to become conditional. This means that in order for it to work with regard to the second Thing, we may have to take into account something about the first Thing. And so it goes. As the theory covers more and more Things, it becomes less precise, less understandable, and parts need to be added on in order cover multiple contingencies. People who go down this path inevitably come to a critical point, at which their theory has become so precisely complicated that it can barely be understood, and gargantuan efforts become necessary to make it work at all. To resolve this impasse, they have a terminological epiphany. They suddenly find a language (that is, an arcane vocabulary) which confers the appearance of simplicity to the morass they have created. Precision is replaced by undefined terms and relationships, described in forceful but impenetrable prose. Argumentation becomes not an activity of rational thought, but a magical experience in which a swirling array of undefined concepts assembles itself in just the right way to come to whatever conclusion is desired. In the mouth of its inventor the theory does indeed explain everything, but in the ears of the audience it explains nothing. (shrink)

Buchanan and Kelley provide a sophisticated and thoughtful critique of contemporary discussions of biosecurity. They provide sound critiques of American biodefence institutions, and the general sense of imminent threat underlying the rush to fund biodefence. However, the essay consistently misrepresents the breadth and depth of scholarly research on the ethics and politics of biodefence.

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 337 Quodlibetal Questions. By WILLIAM OF OcKHAM. Vol. 1 trans. Alfred J. Freddoso and Francis E. Kelley; vol. 2 trans. Alfred J. Freddoso ; pref. Norman Kretzmann. Vol. l of the Yale Library of Medieval Philosophy. New Haven and London: Yale University Press, 1991. Pp. 391 and 305. $100.00 for both (cloth). In these handsome volumes, Professor Alfred J. Freddoso and the late Professor Frank E. (...) Kelley have provided the scholarly community with an English translation of William of Ockham's Quodlibeta septem (hereafter QS). The volumes constitute the first volume in the new Yale Library of Medieval Philosophy, and both the new series and this first contribution within it will add generously to the growing num· her of medieval philosophical texts available in English. Using the critical edition of Ockham's Latin text established by the Rev. Joseph C. Wey (Opera theologica, vol. 9, Franciscan Institute: St. Bonaventure, NY, 1980) as the basis for their work, the translators offer to readers of English an accurate translation of one of Ockham's mature theological works, treating a wide variety of philosophical and theological topics. Indeed, thanks to their efforts, the broad range of Ockham's thought in natural and revealed theology, ontology, epistemology, and ethics becomes available in English for the first time. The purpose of the Yale series is to translate into English " complete works of philosophical and historical importance". In deciding which work of Ockham to translate for the series, the translators faced two potential hazards: the danger of translating one of Ockham's earlier works that might contain ideas which he subsequently reconsidered; and the danger of translating a work that focused upon a narrow range of topics, something which would give readers the false impression that Ockham's philosophy was concerned only with those topics. The translators have adroitly managed to avoid both of these potential hazards. The translators certainly steered clear of the first hazard by deciding to translate Ockham's QS. These quodlibetal questions are believed to represent the substance of disputations Ockham held at the Franciscan studium in London during the years 1322-1324, although the final written form of the work probably was not established until 1325 or shortly thereafter at Avignon. Hence the QS represent to a large extent Ockham's final word on the topics discussed, since in the period after 1325 up until the time of his death in 1347 Ockham was too heavily embroiled in ecclesiological and political controversies in Avignon and Munich to give much consideration to more speculative concerns. Yet the translators also avoided the second hazard by choos- 338 BOOK REVIEWS ing to translate the QS. True, the QS is akin to numerous other medieval quodlibetal questions in that it treats an array of questions; hut, in the case of Ockham's work, the range of topics is so broad and the issues broached therein so fundamental to his personal thought that one has, in effect, a compendium of Ockham's major philosophical and theological ideas. A brief glance at the table of questions indicates the breadth of the questions and their relevance to perennial philosophical discussions. In the area of philosophical theology, Ockham asks whether it can be proved by natural reason that there is only one God; whether it can be proved by natural reason that God's power is infinite; whether God could have made the world from eternity. In regard to ethical theory, Ockham asks whether the exterior act has its own proper moral goodness, and whether there can be a demonstrative science about morals. In fields of epistemology and the philosophy of mind, Ockham asks whether the human intellect knows its own acts intuitively in this life; whether it knows sensible things intuitively; and whether there can be an intuitive cognition of a non-existent object. Closer to the area of logic and semantics, Ockham raises several questions about the status of propositions and their components: whether a mental proposition is composed of things or concepts; whether mental names are divided into concrete and abstract names in the manner of spoken names; whether the object of a definition is an extra-mental reality or a concept. Finally, readers... (shrink)

Contributors:Todd Alden, Lisa Anne Auerbach, Georges Bataille, Jean Baudrillard, David Brown, Gilles Deleuze, Craig Ellwood, Bob Flanagan, Michel Foucault, Jeremy Gilbert-Rolfe, Mike Kelley, Joseph Kosuth, Chris Kraus, Julia Kristeva, Don Kubly, Sylvère Lotringer, Deran Ludd, John Miller, Eileen Myles, Darcy Jo Paley, Ann Rower, Sue Spaid, Frances Stark, Mark Stritzel, James Tyler.

With agile, pathbreaking use of psychoanalytic theory, Tate explores African-American desire, alienation, and subjectivity in neglected novels by Emma Kelley, W.E.B. Du Bois, Richard Wright, Zora Neale Hurston, and Nella Larsen.

Books Reviewed in this Article: Transforming Bible Study. By Walter Wink. Pp.175, London, SCM Press, 1981, £3.50. Isaiah 1–39. By R.E. Clements. Pp.xvi. 301, London, Marshall, Morgan and Scott, 1980, £3.95. Isaiah 40–66. By R.N. Whybray. Pp.301, London, Marshall, Morgan and Scott, 1975, Reprinted 1981, £3.95. Die Gestalt Jesu in den synoptischen Evangelien. By Heinrich Kahlefeld. Pp.264, Frankfurt, Verlag Josef Knecht, 1981, no price given. Following Jesus: Discipleship in the Gospel of Mark. By Ernest Best. Pp.283, Sheffield, JSOT Press, 1981, (...) £15.00, £5.95. The Origin of Paul's Gospel. By Seyoon Kim. Pp.xii, 391, Tübingen, J.C.B. Mohr, 1981, 78 DM. An die Römer. By Ernst Käsemann. Pp.xvi, 411, Tübingen, J.C.B. Mohr, 1980, 48 DM. Les Récits de Resurrection des Morts dans le Nouveau Testament. By Gerard Rochais. Pp.xv, 252, Cambridge, Cambridge University Press, 1981, £15.00. Prêtres Anciens, Prétre Nouveau selon le Nouveau Testament. By Albert Vanhoye. Pp.366, Paris Editions du Seuil, 1980, no price given. Woman in the World of Jesus. By Evelyn and Frank Stagg. Pp.292, Edinburgh, The St Andrew Press, 1981, no price given. Jesus, Man and the Church. By Karl Rahner. Pp.260, London, Darton Longman & Todd, 1981, £14.50. Jesus Lord and Savior: A Theopathic Christology and Soteriology. By William M. Thompson. Pp.ix, 287, Leominster, Fowler Wright, 1981, £7.45. God and World in Schleiermacher's ‘Dialektik’ and ‘Glaubenslehre’. Criticism and the Methodology of Dogmatics. By John E. Thiel. Pp.xiv, 239, Bern, Frankfurt and Las Vegas, Peter Lang, 1981, SF 49.50. Ministry: A Case for Change. By Edward Schillebeeckx. Pp.ix, 165, London, SCM Press, 1981, £4.95. The Sacraments: Readings in Contemporary Sacramental Theology. Edited by Michael J. Taylor. Pp.274, New York, Alba House, 1981, $7.95. Believing in the Church: The Corporate Nature of Faith. A Report by the Doctrine Commission of the Church of England. Pp.ix, 310, London, SPCK, 1981, £8.50. Confessing the Faith in the Church of England Today. By R.T. Beckwith. Pp.36, Oxford, La timer House, 1981, £1.00. A Kind of Noah's Ark? The Anglican Commitment to Comprehensiveness. By J.I. Packer. Pp.39, Oxford, Latimer House, 1981, £1.00. Reasonable Belief: A Survey of the Christian Faith. By Anthony Hanson and Richard Hanson. Pp.xii, 283, Oxford University Press, 1981, £8.50. Doctrine in the Church of England. The 1938 Report with a new introduction by G.W.H. Lampe. Pp.lx, 242, London, SPCK, 1982, £8.50. The Divine Right of the Papacy in Recent Ecumenical Theology. By J. Michael Miller. Pp.xvi, 322, Rome, Università Gregoriana Editrice, 1980, 18,000 Lire. Der heilige Geist in der Theologie von Heribert Mühlen: Versucheiner Darstellung und Würdigung. By John B. Banawiratma. Pp.ix, 310, Frankfurt and Bern: Peter D. Lang, 1981, SFr. 60.00. Standing Before God: Studies on Prayer in Scriptures and Tradition with Essays in Honor of John M. Oesterreicher. Edited by Asher Frinkel and Lawrence Frizzell. Pp.410, New York, Ktav Publishing House, 1981, $29.50. Judaism and Healing. By J. David Bleich. Pp.xiii, 199, New York, Ktav, 1981, $15.00. The Diversity of Moral Thinking. By Neil Cooper. Pp.x, 303, Oxford, Clarendon Press: Oxford University Press, 1981, £15.00. L'Homme: Sujet ou Objet? By Jacques Croteau. Pp.260, Montreal, Bellarmin: Tournai, Desclée et Cie, 1981, $15.00. The Texture of Knowledge: An Essay on Religion and Science. By James W. Jones. Pp.97, Washington, University Press of America, 1981, no price given. Cosmos and Creator. By Stanley L. Jaki. Pp.xii, 168, Edinburgh, Scottish Academic Press, 1980, £6.75. Dante, Philomythes and Philosopher: Man in the Cosmos. By Patrick Boyde. Pp.vii, 408, Cambridge, Cambridge University Press, 1981, £30.00. Dissidence et Philosophie au Mayen Âge. By E.L. Fortin. Pp.201, Montreal, Bellarmin, 1981, $12.00. The Philosophy of John Norris of Bemerton. By Richard Acworth. Pp.x, 388, Hildesheim, Georg Olms, 1979, 74 DM. Philosophy and Ideology in Hume's Political Thought. By David Miller. Pp.xii, 218, Oxford, Clarendon Press, 1981, £15.00. Hegelianism. By John Edward Toews. Pp.x, 450, Cambridge, Cambridge University Press, 1980, £25.00. One Hundred Years of Thomism. Edited by V.B. Brezik. Pp.210, Houston, Centre for Thomistic Studies, 1981, no price given. Gramsci's Political Thought: Hegemony, Consciousness and the Revolutionary Process. By J.V. Femia. Pp.xiii, 303, Oxford, Clarendon Press, 1981, £17.50. Greek and Roman Slavery. By Thomas Wiedemann. Pp.xvi, 284, London, Croom Helm, 1981, £10.95, £5.95. Prophecy and Millenarianism. Essays in Honour of Marjorie Reeves. Edited by Ann Williams. Pp.x, 355, London, Longman, 1980, £25.00. Of Prelates and Princes: A Study of the Economic and Social Position of the Tudor Episcopate. By Felicity Heal. Pp.xv, 353, Cambridge, Cambridge University Press, 1980, £17.50. Radical Religious Movements in Early Modern Europe. By Michael Mullett. Pp.xxiv, 193, London, George Allen & Unwin, 1980, £10.50. The Jesuits. By J.C.H. Aveling. Pp.390, London, Blond and Briggs, 1981, £16.95. The Beginnings of Ideology. By Donald R. Kelley. Pp.xv, 351, Cambridge, Cambridge University Press, 1981, £24.00. Utopia and the Ideal Society: A Study of English Utopian Writing 1516–1700. By J.C. Davis. Pp.x, 427, Cambridge, Cambridge University Press, 1981, £25.00. Eastern Politics of the Vatican 1917–1979. By Hansjakob Stehle. Pp.466, Athens, Ohio University Press, 1981, £16.20, £8.10. Structuralism or Criticism? By Geoffrey Strickland. Pp.viii, 209, Cambridge, Cambridge University Press, 1981, £17.50. The Call of God: The Theme of Vocation in the Poetry of Donne and Herbert. By Robert B. Shaw. Pp.xiii, 123, Cambridge, Mass., Cowley Publications, 1981, $5.00. John and Charles Wesley: Selected Prayers, Hymns, Journal Notes, Sermons, Letters and Treatises. Edited by Frank Whaling. Pp.xx, 412, London, SPCK, 1981, £8.95. The Trickster in West Africa: A Study of Mythic Irony and Sacred Delight. By Robert D. Pelton. Pp.312, Berkeley, University of California Press, 1980, £15.00. (shrink)

This piece takes its cue from Malcolm Bowie's ‘speech creatures’, at once Aristotelian and psychoanalytic, to compare two forceful male characters in English novels who each make speeches proclaiming their own emotional reformation. Different as they are in other respects — an ex-libertine and a man of morals — Samuel Richardson's ‘Mr B.’ and Jane Austen's Mr Darcy both denounce their early parental education in relation to the humbler selfhood their wives-to-be have taught them. Such a development is both (...) like and unlike the later model of psychoanalytic re-education. It takes early emotional malformation as given, and it postulates the possibility of a beneficial re-education in later life; but it does not differentiate between the sexes, and it makes overall for a much more complete transformation and ‘cure by love’ than Freud's theories imagined. (shrink)

Koonin argues that CRISPR-Cas systems present the best-known case in point for Lamarckian evolution because they satisfy his proposed criteria for the specific inheritance of acquired adaptive characteristics. We see two interrelated issues with Koonin’s characterization of CRISPR-Cas systems as Lamarckian. First, at times he appears to confuse an account of the CRISPR-Cas system with an account of the mechanism it employs. We argue there is no evidence for the CRISPR-Cas system being “Lamarckian” in any sense. Second, it is unclear (...) whether the mechanism is more “Lamarckian” than many other forms of genetic change already well-characterized in Darwinian terms. We present three conceptually distinct senses in which the mechanism of IAC may be considered Lamarckian and argue that only the strongest sense of goal-directed IAC would be difficult to accommodate in a Darwinian account. As the CRISPR-Cas mechanism does not qualify as “Lamarckian” in this strong sense, we argue there is no conceptual value in calling it “Lamarckian”. Finally, we suggest that CRISPR-Cas systems do hold the potential for genuinely non-Darwinian, directed evolution in a way that Koonin did not discuss, involving their potential use as a human gene-editing tool. (shrink)

This book applies philosophical hermeneutics to biblical studies. Whereas traditional studies of the Bible limit their analysis to the exploration of the texts' original historical sense, this book discusses how to move beyond these issues to a consideration of biblical texts' existential significance for the present. In response to the rejection of biblical significance in the late nineteenth century and the accompanying crisis of nihilism, B. H. McLean argues that the philosophical thought of Heidegger, Bultmann, Gadamer, Habermas, Ricoeur, Levinas, Deleuze (...) and Guattari provides an alternative to historically oriented approaches to biblical interpretation. He uses basic principles drawn from these philosophers' writings to create a framework for a new 'post-historical' mode of hermeneutic inquiry that transcends the subject-based epistemological structure of historical positivism. (shrink)

David Lewis‘s Parts of Classes is a great book, in all respects. But one of its most interesting thesis, in my mind, is not its core thesis that standard set theory — ZFC — reduces to classical mereology + plural quantification + a primitive singleton-relation, but rather its sub-thesis of how to understand classical mereology, what Lewis calls the thesis of Composition as Identity: (CAI): a whole is the same portion of reality as its many parts taken together; it is (...) them collectively, they collectively are it. CAI is needed as an assumption for the core thesis of Parts of Classes — the reduction of ZFC — on pain of it being unmotivated.1 But CAI is the most interesting in its own right. It is also as such it is presented by Lewis, and received in the literature. In what follows, I critically assess CAI as Lewis presents it in Parts of Classes. I first argue that Lewis‘s presentation of CAI has been misunderstood in the literature (section 1). I then argue that the best (if not the only) way to understand it entails a slightly revisionary semantics for a certain form of predication (section 2). I finally end by showing that this might create more trouble than it solves for Lewis (section 3). (shrink)

We investigated the competition between automatic and controlled processes in a word stem completion task. Prime-display duration and the prime-target interval were manipulated. On each trial a masked prime was displayed briefly, followed either immediately or after a delay by a word stem. The subjects were required to complete each stem with the first word that came to mind, to report any prime they could identify, and not to give as completion any identified prime. By the assumption that automatic processes (...) require less stimulus input and can be completed faster than consciously controlled processes we expected a stronger performance contribution from automatic processes with the shorter prime-display durations and in the immediate stems condition. The results confirmed this expectation. The findings highlight that consciously controlled processes require more time to run their course than unconscious automatic processes. (shrink)

Russell's new theory of denoting phrases introduced in "On Denoting" in Mind 1905 is now a paradigm of analytic philosophy. The main argument for Russell's new theory is the so-called 'Gray's Elegy' argument, which purports to show that the theory of denoting concepts promoted by Russell in the 1903 Principles of Mathematics is incoherent. The 'Gray's Elegy' argument rests on the premise that if a denoting concept occurs in a proposition, then the proposition is not about the concept. I argue (...) that the premise is false. The 'Gray's Elegy' argument does not exhaust Russell's ammunition against the theory of denoting concepts. Another reason Russell rejects the theory is, as he says, that it cannot provide an adequate account of non-uniquely denoting concepts. In the last section of the paper, I argue that even though Russell was right in thinking that the theory of denoting concepts cannot provide an adequate account of non-uniquely denoting concepts, Russell's new theory does not succeed in eliminating the occurrence of all denoting concepts, as it requires a commitment to the existence of variables that indirectly denote their values. However, the view that variables are denoting concepts is unproblematic once the 'Gray's Elegy' argument is blocked. (shrink)

Using the principles and sometimes the conclusions of his teacher Adolf Stöhr, Cleve insists that he is giving a philosophical interpretation and not simply a philological reconstruction of these Pre-Socratics. The philosophers have been divided into 1) "Religious Reformers", 2) "Philosophers of Nature", 3) "Champions of Culture Politics"—"The Glossomorphics". There will certainly be disagreement on some of Cleve's interpretations but it must be said that Cleve carries through his philosophical reconstruction with admirable lucidity and consistency though, occasionally, some of his (...) criticisms of the "philologists" are rather waspish. Nevertheless, this is a splendid and important study which is a tribute to the author's erudition and insight.—D. J. B. (shrink)

Modern science developed in the interflow of culture between west and east. Combing of pratice technology with philosophic thoughts formed experimental method. Holistic views contacting atomism produced system theory. System thoughts are applicated in the science and engineering of biosystems, and the cencepts of system biomedicine (Kamada T.1992), systems biology (Zieglgansberger W, Tolle TR.1993), system bioengineering and system genetics (Zeng BJ. 1994) were established. From positive to synthetic thoughts, philosophy have been developed ontology, cosmology, organism theories. Structurity is structure logic (...) system founded on entity, develop, exist axioms, tolerance, adaptation, fluctuate, interweave, transform theorems and integrate, adaptation, construct laws. Structurity be discussed on the cosmos, life, culture system, creation, hologram theories of structure ontology, construct mutation, simi-structure organism and entity emergence, symbol implication. From the relation of structure, function and development, the structurity put forward the cycle, spiral, triangle structure stability patterns of self-organization in structure complement each other and stratification, functional couple and interflow bounds growth, coordinativetransformation and holographic symmetry. (shrink)

Ten new graduate speech pathologists recounted their experiences in managing workplace ethical dilemmas in semi-structured interviews. Their stories were analysed for elements that described the nature and management of the ethical dilemmas. Ethical reasoning themes were generated to reflect the participants’ approaches to managing these dilemmas. Finally, a conceptual model, the Dynamic Model of Ethical Reasoning, was developed. This model incorporates the elements of awareness, independent problem solving, supported problem solving, and decision and outcome evaluation. Features of the model demonstrate (...) the complexity of ethical reasoning and the challenges that new graduates encounter when managing ethical dilemmas. The results have implications for preparing new graduates to manage ethical dilemmas in the workplace. (shrink)

Some believe that there is a God who is the source of all things; and some believe that there are necessarily existing abstract objects. But can one believe both these things? That is the question of this Element. First, Einar Duenger Bøhn clarifies the concepts involved, and the problem that arises from believing in both God and abstract objects. Second, he presents and discusses the possible kinds of solutions to that problem. Third, Bøhn discusses a new kind of solution to (...) the problem, according to which reality is most fundamentally made of information. (shrink)